Immunogenicity of Danish-SSI 1331 BCG vaccine in the UK: Comparison with Glaxo-Evans 1077 BCG vaccine


Gorak-Stolinska, P; Weir, RE; Floyd, S; Lalor, MK; Stenson, S; Branson, K; Blitz, R; Luke, S; Nazareth, B; Ben-Smith, A; Fine, PEM; Dockrell, HM; (2006) Immunogenicity of Danish-SSI 1331 BCG vaccine in the UK: Comparison with Glaxo-Evans 1077 BCG vaccine. Vaccine, 24 (29-30). pp. 5726-5733. ISSN 0264-410X DOI: 10.1016/j.vaccine.2006.04.037

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Abstract

The immunogenicity and reactogenicity, in British schoolchildren, of the newly introduced Danish-SSI 1331 BCG vaccine was compared with that of the previously used Glaxo-Evans 1077 BCG vaccine. Interferon-gamma (IFN-gamma) response to M. tuberculosis purified protein derivative (M.tb PPD) in a 6-day whole blood assay and delayed type hypersensitivity (DTH) to tuberculin PPD were determined before and 1 year after receiving BCG or no vaccination. Scar size was measured I year after vaccination. There was no evidence of a difference in immunogenicity (IFN-gamma and DTH conversion rates) but evidence of lower reactogenicity (scar size) with Danish-SSI 1331 compared to Glaxo-Evans 1077 vaccines. (c) 2006 Elsevier Ltd. All rights reserved.

Item Type: Article
Keywords: BCG, vaccination, immune responses, Mycobacterium-tuberculosis, interferon-gamma, subunit vaccine, skin-test, northern malawi, south-india, efficacy, antigens, schoolchildren, protection
Faculty and Department: Academic Services & Administration > Academic Administration
Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Research Centre: TB Centre
Vaccine Centre
Population Studies Group
PubMed ID: 16723176
Web of Science ID: 239081600009
URI: http://researchonline.lshtm.ac.uk/id/eprint/11612

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