Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains.
Gemma, S; Kukreja, G; Fattorusso, C; Persico, M; Romano, MP; Altarelli, M; Savini, L; Campiani, G; Fattorusso, E; Basilico, N; Taramelli, D; Yardley, V; Butini, S; (2006) Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains. Bioorganic & medicinal chemistry letters, 16 (20). pp. 5384-8. ISSN 0960-894X DOI: 10.1016/j.bmcl.2006.07.060
A series of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones were synthesized and tested for their antimalarial properties. These compounds showed remarkable anti-plasmodial activity in vitro especially against chloroquine-resistant strains. Their potent biological activity makes them promising lead structures for the development of new antimalarial drugs.
|Faculty and Department:||Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection|
|Research Centre:||Antimicrobial Resistance Centre (AMR)|
|Web of Science ID:||241344400027|
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