Differential polyadenylation of ribosomal RNA during post-transcriptional processing in Leishmania.


Decuypere, S; Vandesompele, J; Yardley, V; De Donckeri, S; Laurent, T; Rijal, S; Llanos-Cuentas, A; Chappuis, F; Arevalo, J; Dujardin, JC; (2005) Differential polyadenylation of ribosomal RNA during post-transcriptional processing in Leishmania. Parasitology, 131 (Pt 3). pp. 321-9. ISSN 0031-1820 DOI: https://doi.org/10.1017/s0031182005007808

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Abstract

The protozoan parasite Leishmania belongs to the most ancient eukaryotic lineages and this is reflected in several distinctive biological features, such as eukaryotic polycistronic transcription and RNA trans-splicing. The disclosure of this organism's unusual characteristics leads to a better understanding of the origin and nature of fundamental biological processes in eukaryotes. Here we report another unusual phenomenon as we demonstrate that precursor ribosomal RNA can be extensively polyadenylated during post-transcriptional processingt. Furthermore, we demonstrate that the degree of precursor rRNA polyadenylation is variable in different strains and in the different life-stages of a strain.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Research Centre: Leishmaniasis Group
PubMed ID: 16178353
Web of Science ID: 232315600005
URI: http://researchonline.lshtm.ac.uk/id/eprint/11596

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