Moxifloxacin and pyrazmamide susceptibility testing in a complex case of multidrug-resistant tuberculosis


Feasey, NA; Pond, M; Coleman, D; Solomon, AW; Cosgrove, CA; Delgado, R; Butcher, PD; Mitchison, DA; Harrison, T; (2011) Moxifloxacin and pyrazmamide susceptibility testing in a complex case of multidrug-resistant tuberculosis. The international journal of tuberculosis and lung disease, 15 (3). pp. 417-420. ISSN 1027-3719

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Abstract

Multidrug-resistant tuberculosis (MDR-TB) is a public health problem of global concern. It is critical that drug susceptibility testing (DST) methods accurately predict clinical response. We present a patient with a challenging case of MDR-TB with additional resistance to quinolones and pyrazinamide. Treatment with a regimen including high-dosage moxifloxacin, based on additional genotypic and phenotypic DST, produced excellent results. This case highlights the possibility of treatment with high-dose fluoroquinolones despite apparent bacterial resistance to these agents. Improved DST methods are necessary for both agents. Development of genotypic approaches may offer a susceptibility profile rapidly, enabling early introduction of individualised treatments.

Item Type: Article
Keywords: tuberculosis, multidrug-resistant, fluoroquinolones, pyrazinamide, MYCOBACTERIUM-TUBERCULOSIS, TUBERCLE-BACILLI, MUTATIONS
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
PubMed ID: 21333115
Web of Science ID: 287984200023
URI: http://researchonline.lshtm.ac.uk/id/eprint/1146

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