Haemoglobin C protects against clinical Plasmodium falciparum malaria.

Modiano, D; Luoni, G; Sirima, BS; Simpore, J; Verra, F; Konate, A; Rastrelli, E; Olivieri, A; Calissano, C; Paganotti, GM; D'Urbano, L; Sanou, I; Sawadogo, A; Modiano, G; Coluzzi, M; (2001) Haemoglobin C protects against clinical Plasmodium falciparum malaria. Nature, 414 (6861). pp. 305-8. ISSN 0028-0836 DOI: https://doi.org/10.1038/35104556

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Haemoglobin C (HbC; beta6Glu --> Lys) is common in malarious areas of West Africa, especially in Burkina Faso. Conclusive evidence exists on the protective role against severe malaria of haemoglobin S (HbS; beta6Glu --> Val) heterozygosity, whereas conflicting results for the HbC trait have been reported and no epidemiological data exist on the possible role of the HbCC genotype. In vitro studies suggested that HbCC erythrocytes fail to support the growth of P. falciparum but HbC homozygotes with high P. falciparum parasitaemias have been observed. Here we show, in a large case-control study performed in Burkina Faso on 4,348 Mossi subjects, that HbC is associated with a 29% reduction in risk of clinical malaria in HbAC heterozygotes (P = 0.0008) and of 93% in HbCC homozygotes (P = 0.0011). These findings, together with the limited pathology of HbAC and HbCC compared to the severely disadvantaged HbSS and HbSC genotypes and the low betaS gene frequency in the geographic epicentre of betaC, support the hypothesis that, in the long term and in the absence of malaria control, HbC would replace HbS in central West Africa.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
Research Centre: Malaria Centre
PubMed ID: 11713529
Web of Science ID: 172150700043
URI: http://researchonline.lshtm.ac.uk/id/eprint/11408


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