Association between psychological symptoms in adults and growth in early life: longitudinal follow up study.


Cheung, YB; Khoo, KS; Karlberg, J; Machin, D; (2002) Association between psychological symptoms in adults and growth in early life: longitudinal follow up study. BMJ (Clinical research ed), 325 (7367). p. 749. ISSN 0959-8138 DOI: https://doi.org/10.1136/bmj.325.7367.749

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Abstract

OBJECTIVES: To test the hypothesis that birth weight for gestational age and weight gain in early childhood have a long term association with psychological distress in adults. DESIGN: Longitudinal study of 1958 birth cohort followed to age 42 years. Setting: Population based birth cohort study. PARTICIPANTS: 9731 cohort members with valid perinatal, postnatal, and adult data. MAIN OUTCOME MEASURES: Malaise inventory scores measured at ages 23, 33, and 42 years. Generalised estimating equations approach used to analyse repeated measures. RESULTS: Psychological distress score was inversely related to birthweight z score and weight gain from birth to the age of 7 years. A unit increase in birthweight z score or childhood weight gain was associated with a mean reduction in psychological distress score of 0.10 (95% confidence interval 0.05 to 0.15) and 0.06 (0.02 to 0.10), respectively. Birth weight and weight gain were also inversely related to the odds of having a high level of psychological distress, with odds ratios being 0.90 (0.85 to 0.95) and 0.93 (0.89 to 0.98), respectively. CONCLUSIONS: Psychological health in adults is related to fetal growth and growth in early childhood.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: Tropical Epidemiology Group
PubMed ID: 12364303
Web of Science ID: 178537300017
URI: http://researchonline.lshtm.ac.uk/id/eprint/11272

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