Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes.


Rafiq, S; Melzer, D; Weedon, MN; Lango, H; Saxena, R; Scott, LJ; DIAGRAM Consortium, ; Palmer, CN; Morris, AD; McCarthy, MI; Ferrucci, L; Hattersley, AT; Zeggini, E; Frayling, TM; (2008) Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes. Diabetologia, 51 (12). pp. 2205-13. ISSN 0012-186X DOI: https://doi.org/10.1007/s00125-008-1160-3

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Abstract

There are strong associations between measures of inflammation and type 2 diabetes, but the causal directions of these associations are not known. We tested the hypothesis that common gene variants known to alter circulating levels of inflammatory proteins, or known to alter autoimmune-related disease risk, influence type 2 diabetes risk.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
PubMed ID: 18853133
Web of Science ID: 260686000008
URI: http://researchonline.lshtm.ac.uk/id/eprint/1125

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