An interleukin-18 polymorphism is associated with reduced serum concentrations and better physical functioning in older people.


Frayling, TM; Rafiq, S; Murray, A; Hurst, AJ; Weedon, MN; Henley, W; Bandinelli, S; Corsi, AM; Ferrucci, L; Guralnik, JM; Wallace, RB; Melzer, D; (2007) An interleukin-18 polymorphism is associated with reduced serum concentrations and better physical functioning in older people. The journals of gerontology Series A, Biological sciences and medical sciences, 62 (1). pp. 73-8. ISSN 1079-5006 DOI: https://doi.org/10.1093/gerona/62.1.73

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Abstract

The proinflammatory cytokine interleukin-18 (IL-18) is associated with major disabling conditions, although whether as byproduct or driver is unclear. The role of common variation in the IL-18 gene on serum concentrations and functioning in old age is unknown.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
PubMed ID: 17301041
Web of Science ID: 247220200011
URI: http://researchonline.lshtm.ac.uk/id/eprint/1121

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