Vascular and Alzheimer's disease markers independently predict brain atrophy rate in Alzheimer's Disease Neuroimaging Initiative controls


Barnes, J; Carmichael, OT; Leung, KK; Schwarz, C; Ridgway, GR; Bartlett, JW; Malone, IB; Schott, JM; Rossor, MN; Biessels, GJ; Decarli, C; Fox, NC; Alzheimer's Dis Neuroimaging, Initi; (2013) Vascular and Alzheimer's disease markers independently predict brain atrophy rate in Alzheimer's Disease Neuroimaging Initiative controls. Neurobiology of aging, 34 (8). pp. 1996-2002. ISSN 0197-4580 DOI: https://doi.org/10.1016/j.neurobiolaging.2013.02.003

[img]
Preview
Text - Published Version
License:

Download (275kB) | Preview

Abstract

This study assessed relationships among white matter hyperintensities (WMH), cerebrospinal fluid (CSF), Alzheimer's disease (AD) pathology markers, and brain volume loss. Subjects included 197 controls, 331 individuals with mild cognitive impairment (MCI), and 146 individuals with AD with serial volumetric 1.5-T MRI. CSF A beta 1-42 (n = 351) and tau (n = 346) were measured. Brain volume change was quantified using the boundary shift integral (BSI). We assessed the association between baseline WMH volume and annualized BSI, adjusting for intracranial volume. We also performed multiple regression analyses in the CSF subset, assessing the relationships of WMH and A beta 1-42 and/or tau with BSI. WMH burden was positively associated with BSI in controls (p = 0.02) but not MCI or AD. In multivariable models, WMH (p = 0.003) and A beta 1-42 (p = 0.001) were independently associated with BSI in controls; in MCI A beta 1-42 (p < 0.001) and tau (p = 0.04) were associated with BSI. There was no evidence of independent effects of WMH or CSF measures on BSI in AD. These data support findings that vascular damage is associated with increased brain atrophy in the context of AD pathology in pre-dementia stages. (c) 2013 Elsevier Inc. All rights reserved.

Item Type: Article
Keywords: Alzheimer's disease, Vascular disease, Mild cognitive impairment (MCI), Volumetric MRI, Normal aging, mild cognitive impairment, matter hyperintensity volume, prevention, trials, mri, dementia, biomarkers, progression, decline, lesions, heart
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Medical Statistics
PubMed ID: 23522844
Web of Science ID: 319803100008
URI: http://researchonline.lshtm.ac.uk/id/eprint/1105295

Statistics


Download activity - last 12 months
Downloads since deposit
259Downloads
331Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item