Serum CCL11 (eotaxin-1) and CCL17 (TARC) are serological indicators of multiple helminth infections and are driven by Schistosoma mansoni infection in humans


Geiger, SM; Jardim-Botelho, A; Williams, W; Alexander, N; Diemert, DJ; Bethony, JM; (2013) Serum CCL11 (eotaxin-1) and CCL17 (TARC) are serological indicators of multiple helminth infections and are driven by Schistosoma mansoni infection in humans. Tropical medicine & international health, 18 (6). pp. 750-760. ISSN 1360-2276 DOI: https://doi.org/10.1111/tmi.12095

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Abstract

OBJECTIVES To evaluate systemic serum cytokine and chemokine markers for inflammation and Th1/Th2 responses in relation to multiple helminth infections, parasite burden and/or nutritional status of individuals. METHODS In a longitudinal study, stool samples from 210 individuals from an area highly endemic for Ascaris lumbricoides, Necator americanus and Schistosoma mansoni were examined before and 12 months after clearance of parasites by chemotherapy. On both occasions, the presence of mono- or multiple infections and intensities of infection were compared with nutritional parameters and with serum cytokines or chemokines as markers for inflammatory, regulatory or Th1- or Th2-type immune responses. RESULTS Before treatment, we were not able to associate any altered nutritional parameters with increased inflammatory responses, and highest intensities of infection were found in eutrophic participants with multiple infections. In contrast, major changes in serum Th2-type chemokine levels were measured in individuals infected with intestinal helminths and/or S. mansoni, and resulted in significantly higher CCL11 and CCL17 concentrations, both before treatment and after reinfection. CONCLUSIONS The driving force for these elevated type 2 serum chemokine concentrations was an S. mansoni infection and faecal egg counts significantly correlated with serum IL-10 concentrations.

Item Type: Article
Keywords: hookworm, Ascaris lumbricoides, Schistosoma mansoni, immune response, CCL11, CCL17, in-vivo, antiparasite treatment, necator-americanus, cytokine responses, chemokine, hookworm, children, protein, il-10, mice, Adolescent, Adult, Aged, Animals, Anthelmintics, therapeutic use, Biological Markers, blood, Brazil, Chemokine CCL11, blood, Chemokine CCL17, blood, Child, Feces, parasitology, Female, Humans, Interleukin-10, blood, Longitudinal Studies, Male, Middle Aged, Parasite Egg Count, Schistosoma mansoni, isolation & purification, Schistosomiasis mansoni, blood, diagnosis, drug therapy, Th1 Cells, immunology, Th2 Cells, immunology, Young Adult
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: Tropical Epidemiology Group
PubMed ID: 23496801
Web of Science ID: 320334600011
URI: http://researchonline.lshtm.ac.uk/id/eprint/1105270

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