Early introduction of root vegetables in infancy associated with advanced ß-cell autoimmunity in young children with human leukocyte antigen-conferred susceptibility to Type?1 diabetes.


Virtanen, SM; Takkinen, HM; Nevalainen, J; Kronberg-Kippilä, C; Salmenhaara, M; Uusitalo, L; Kenward, MG; Erkkola, M; Veijola, R; Simell, O; Ilonen, J; Knip, M; (2011) Early introduction of root vegetables in infancy associated with advanced ß-cell autoimmunity in young children with human leukocyte antigen-conferred susceptibility to Type?1 diabetes. Diabetic medicine. ISSN 0742-3071 DOI: https://doi.org/10.1111/j.1464-5491.2011.03294.x

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Abstract

Aims? Early introduction of supplementary foods has been implicated to play a role in the development of ß-cell autoimmunity. We set out to study the effects of breastfeeding and age at introduction of supplementary foods on the development of ß-cell autoimmunity. Methods? A prospective birth cohort of 6069 infants with HLA-DQb-conferred susceptibility to Type?1 diabetes was recruited between 1996 and 2004. Antibodies against islet cells, insulin, glutamate dehydroxylase and islet antigen?2 were measured at 3- to 12-month intervals. The families recorded at home the age at introduction of new foods and, for each visit, completed a structured dietary questionnaire. The endpoint was repeated positivity for islet cell antibodies plus at least one other antibody and/or clinical Type?1 diabetes (n?=?265). Results? Early introduction of root vegetables (by the age of 4?months) was related to increased risk of developing positivity for the endpoint [hazard ratio (95%?CI) for the earliest third 1.75 (1.11-2.75) and for the middle third 1.79 (1.22-2.62) compared with the last third (>?4?months), likelihood ratio test P?=?0.006], independently of the introduction of other foods and of several putative socio-demographic and perinatal confounding factors. Introducing wheat, rye, oats and/or barley cereals (P?=?0.013) and egg (P?=?0.031) early was related to an increased risk of the endpoint, but only during the first 3?years of life. Conclusions? Early introduction of root vegetables during infancy is independently associated with increased risk of ß-cell autoimmunity among Finnish children with increased genetic susceptibility to Type?1 diabetes.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Medical Statistics
PubMed ID: 21418094
Web of Science ID: 292705100012
URI: http://researchonline.lshtm.ac.uk/id/eprint/1078

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