Evaluation of the meningitis epidemics risk model in Africa.

Savory, EC; Cuevas, LE; Yassin, MA; Hart, CA; Molesworth, AM; Thomson, MC; (2006) Evaluation of the meningitis epidemics risk model in Africa. Epidemiology and infection, 134 (5). pp. 1047-51. ISSN 0950-2688 DOI: https://doi.org/10.1017/S0950268806005929

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Meningitis epidemics have a strong environmental component in Africa with the most severe epidemics occurring in the Sahelian region known as the Meningitis Belt. The objective of this study is to evaluate an ecological model based on absolute humidity and land cover type to predict the location of these epidemics. The risk model is evaluated prospectively based on epidemics occurring in Africa from January 2000 to April 2004. Seventy-one epidemics occurred during this time period affecting 22% of continental African districts. The model predicted their location with a sensitivity of 88%. The evaluation also suggests that epidemics may be extending south of the Sahel, which is consistent with environmental changes in the region. This model could be used to select priority areas for the introduction of the newly developed conjugate meningococcal vaccines. Further studies are needed to enhance our understanding of the complex relationship between meningitis epidemics and the environment.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: Vaccine Centre
PubMed ID: 16476171
Web of Science ID: 241138600020
URI: http://researchonline.lshtm.ac.uk/id/eprint/10773


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