Memory versus naive T-cell migration.


Lewis, M; Tarlton, JF; Cose, S; (2008) Memory versus naive T-cell migration. Immunology and cell biology, 86 (3). pp. 226-31. ISSN 0818-9641 DOI: https://doi.org/10.1038/sj.icb.7100132

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Abstract

Our established understanding of lymphocyte migration suggests that naive and memory T cells travel throughout the body via divergent pathways; naive T cells circulate between blood and lymph whereas memory T cells additionally migrate through non-lymphoid organs. Evidence is now gradually emerging which suggests such disparate pathways between naive and memory T cells may not strictly be true, and that naive T cells gain access to the non-lymphoid environment in numbers approaching that of memory T cells. We discuss here the evidence for naive T-cell traffic into the non-lymphoid environment, compare and contrast this movement with what is known of memory T cells, and finally discuss the functional importance of why naive T cells might access the parenchymal tissues.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
PubMed ID: 17998915
Web of Science ID: 254416200003
URI: http://researchonline.lshtm.ac.uk/id/eprint/1054

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