CD4 T cells inhibit the CD8 T cell response during low-dose virus infection.


Cose, S; Brammer, C; Zammit, DJ; Blair, DA; Lefrançois, L; (2006) CD4 T cells inhibit the CD8 T cell response during low-dose virus infection. International immunology, 18 (8). pp. 1285-93. ISSN 0953-8178 DOI: https://doi.org/10.1093/intimm/dxl061

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Abstract

CD4 T cells are not thought to play a significant role in generating an effective primary CD8 T cell response to most viral infections. We have challenged this view by demonstrating that antigen-specific CD4 T cells can indeed suppress the proliferation of antigen-specific naive CD8 T cells in response to low doses of vesicular stomatitis virus. This finding is in contrast to the established observations that at high antigen loads CD4 T cells play little role in generating CD8 T cell responses, and that in non-infectious model systems CD4 T cells actually help the CD8 T cell response. Our results suggest that at low infectious doses, CD4 T cells play a much larger role in controlling infections than previously appreciated.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
PubMed ID: 16769750
Web of Science ID: 239630400009
URI: http://researchonline.lshtm.ac.uk/id/eprint/1052

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