Evidence that a significant number of naive T cells enter non-lymphoid organs as part of a normal migratory pathway.


Cose, S; Brammer, C; Khanna, KM; Masopust, D; Lefrançois, L; (2006) Evidence that a significant number of naive T cells enter non-lymphoid organs as part of a normal migratory pathway. European journal of immunology, 36 (6). pp. 1423-33. ISSN 0014-2980 DOI: 10.1002/eji.200535539

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Abstract

Only activated and effector memory T cells are thought to access non-lymphoid tissues. In contrast, naive T cells are thought to circulate only between the blood, lymph and secondary lymphoid organs. We examined the phenotype of endogenous T cells in various non-lymphoid organs and showed that a subset of cells exhibited an apparently naive phenotype and were functionally inactive. FTY720 treatment selectively depleted this population from the non-lymphoid tissues. In addition, RAG-deficient TCR transgenic CD4 and CD8 T cells were present in non-lymphoid tissues in bone marrow chimeric mice and in situ imaging analysis revealed their location in the parenchymal tissues. Moreover, migration of TCR transgenic T cells to non-lymphoid tissues after adoptive transfer was pertussis-toxin resistant. Overall, the results suggest that naive T cells may circulate through non-lymphoid tissues as part of their normal migratory pathway.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
PubMed ID: 16708400
Web of Science ID: 238405100008
URI: http://researchonline.lshtm.ac.uk/id/eprint/1051

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