Why do we need quality-assured diagnostic tests for sexually transmitted infections?

Peeling, RW; Mabey, D; Herring, A; Hook, EW; (2006) Why do we need quality-assured diagnostic tests for sexually transmitted infections? Nature reviews Microbiology, 4 (12). pp. 909-921. ISSN 1740-1526 DOI: https://doi.org/10.1038/nrmicro1555

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The bacterial sexually transmitted infections (STIs) syphilis, gonorrhoea and chlamydia can all be cured with a single dose of antibiotic. Unfortunately, however, these infections often remain undiagnosed as many infected individuals have few if any symptoms. Diagnostic tests with high sensitivity and specificity are available for all three infections but, owing to their expense and the lack of laboratory capacity, most people in developing countries do not have access to these tests. There is a great need for simple, cheap diagnostic tests for STIs that can be performed at the point of care, enabling treatment to be given immediately. It is hoped that recent advances in our understanding of the pathogenesis of these infections, and the availability of the complete genome sequences for each causative organism, will lead to the development of improved point-of-care tests that will reduce the burden of these diseases in developing countries.

Item Type: Article
Keywords: ACID AMPLIFICATION TESTS, CHLAMYDIA-TRACHOMATIS INFECTIONS, VIRULENT, TREPONEMA-PALLIDUM, LATEX AGGLUTINATION-TEST, APTIMA COMBO-2 ASSAY, RAPID PLASMA REAGIN, SUB-SAHARAN AFRICA, NEISSERIA-GONORRHOEAE, CONGENITAL-SYPHILIS, ANTENATAL SYPHILIS, Anti-Bacterial Agents, therapeutic use, Bacterial Infections, diagnosis, Bacteriological Techniques, economics, methods, standards, Female, HIV Infections, complications, transmission, Humans, Infant, Infant, Newborn, Male, Pregnancy, Pregnancy Complications, Infectious, diagnosis, prevention & control, Quality Control, Sexually Transmitted Diseases, Bacterial, complications, diagnosis, drug therapy, microbiology
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Research Centre: Centre for Maternal, Reproductive and Child Health (MARCH)
PubMed ID: 17109030
Web of Science ID: 242125000012
URI: http://researchonline.lshtm.ac.uk/id/eprint/10499


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