The associations of birthweight, gestational age and childhood BMI with type 2 diabetes: findings from the Aberdeen Children of the 1950s cohort


Lawlor, DA; Smith, GD; Clark, H; Leon, DA; (2006) The associations of birthweight, gestational age and childhood BMI with type 2 diabetes: findings from the Aberdeen Children of the 1950s cohort. Diabetologia, 49 (11). pp. 2614-2617. ISSN 0012-186X DOI: https://doi.org/10.1007/s00125-006-0408-z

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Abstract

Aims/hypothesis The aim of this study was to examine the associations of birthweight, gestational age and childhood BMI (assessed at a mean age of 5 years) with a self-report of a doctor diagnosis of diabetes in middle age. Methods We studied a birth cohort of 5,793 individuals who were born between 1950 and 1956 in Aberdeen, Scotland, and who responded to a questionnaire administered in 2000. Results Birthweight and gestational age were inversely associated with diabetes. These associations remained with additional adjustment for indicators of childhood and adult socioeconomic position, maternal complications of pregnancy, adult smoking, adult BMI and simultaneous adjustment for each other: the adjusted odds ratio per unit increase in birthweight z score was 0.73 (95% CI 0.60-0.88), the odds ratio per week increase in gestational age was 0.91 (95% CI 0.82-1.00) and odds ratio for preterm birth was 2.04 (94% CI 1.18-3.53). The positive association of childhood BMI with diabetes was attenuated on adjustment for adult BMI. Conclusions/interpretation In this population, who were born in the 1950s, poor intrauterine growth and preterm birth are associated with an increased risk of diabetes.

Item Type: Article
Keywords: birthweight, BMI, body mass index, childhood, diabetes, epidemiology, preterm, HEALTH
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
Research Centre: ECOHOST - The Centre for Health and Social Change
Centre for Maternal, Reproductive and Child Health (MARCH)
Centre for Global Non-Communicable Diseases (NCDs)
PubMed ID: 17016693
Web of Science ID: 241578600013
URI: http://researchonline.lshtm.ac.uk/id/eprint/10497

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