Different doses of amodiaquine and chloroquine for treatment of uncomplicated malaria in children in Guinea-Bissau: implications for future treatment recommendations


Kofoed, P.-, E; Ursing, J; Poulsen, A; Rodrigues, A; Bergquist, Y; Aaby, P; Rombo, L; (2007) Different doses of amodiaquine and chloroquine for treatment of uncomplicated malaria in children in Guinea-Bissau: implications for future treatment recommendations. Transactions of the Royal Society of Tropical Medicine and Hygiene, 101 (3). pp. 231-238. ISSN 0035-9203 DOI: 10.1016/j.trstmh.2006.05.008

Full text not available from this repository.

Abstract

The aim of the present study was to compare different doses of chloroquine (CQ) and amodiaquine (AQ) for the treatment of falciparum malaria in children. Children with Plasmodium falciparum monoinfection were allocated by block randomisation to treatment with CQ 50/kg mg or 25mg/kg or AQ 15mg/kg or 30mg/kg. The main outcomes were the cumulative adequate clinical and parasitological response (ACPR) rates and the number of true recrudescences as determined by PCR. A total of 729 children were included. In an evaluability analysis, the PCR-uncorrected cumulative ACPR rates on Day 28 for the treatment groups CQ 50/kg mg or 25mg/kg and AQ 15mg/kg or 30mg/kg were 90%, 76%, 92% and 94%, respectively; the PCR-adjusted ACPR rates on Day 28 were 92%, 80%, 94% and 94%, respectively. No differences in adverse effects were observed. AQ has a high cure rate given as 30mg/kg and 15mg/kg, although it is not superior to treatment with CQ 50mg/kg. However, 25mg/kg of CQ is less efficient. As an interim option, Guinea-Bissau could change the recommended first-line treatment of uncomplicated malaria to CQ 50mg/kg, reserving AQ as a partner drug for a future combination therapy.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Disease Control
Research Centre: Malaria Centre
PubMed ID: 16904718
Web of Science ID: 244130600004
URI: http://researchonline.lshtm.ac.uk/id/eprint/10482

Statistics


Download activity - last 12 months
Downloads since deposit
0Downloads
294Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item