Incidence of epilepsy A systematic review and meta-analysis


Ngugi, AK; Kariuki, SM; Bottomley, C; Kleinschmidt, I; Sander, JW; Newton, CR; (2011) Incidence of epilepsy A systematic review and meta-analysis. Neurology, 77 (10). pp. 1005-1012. ISSN 0028-3878 DOI: https://doi.org/10.1212/WNL.0b013e31822cfc90

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Abstract

Objective: To estimate the pooled incidence of epilepsy from published studies and investigate sources of heterogeneity in the estimates. Methods: We searched online databases for incidence studies and used meta-analytic methods to analyze the data. Results: Thirty-three articles met the entry criteria. The median incidence of epilepsy was 50.4/100,000/year (interquartile range [IQR] 33.6-75.6), while it was 45.0 (IQR 30.3-66.7) for high-income countries and 81.7 (IQR 28.0-239.5) for low- and middle-income countries. Population-based studies had higher incidence estimates than hospital-based studies (p = 0.02) while retrospective study design was associated with lower estimates than prospective studies (p = 0.04). Conclusion: We provide data that could potentially be used to assess the burden and analyze the trends in incidence of epilepsy. Our results support the need for large population-based incidence studies of epilepsy. Neurology (R) 2011;77:1005-1012

Item Type: Article
Keywords: severe falciparum-malaria, sub-saharan africa, generalized epilepsy, seizure disorders, rural bolivia, risk-factors, children, population, prevalence, burundi, eux pm, 2005, v4, p21
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
PubMed ID: 21893672
Web of Science ID: 294538100022
URI: http://researchonline.lshtm.ac.uk/id/eprint/103

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