Long-term effectiveness against cholera of oral killed whole-cell vaccine produced in Vietnam


Thiem, VD; Deen, JL; von Seidlein, L; Canh Do, G; Anh, DD; Park, JK; Ali, M; Danovaro-Holliday, MC; Son, ND; Hoa, NT; Holmgren, J; Clemens, JD; (2006) Long-term effectiveness against cholera of oral killed whole-cell vaccine produced in Vietnam. Vaccine, 24 (20). pp. 4297-303. ISSN 0264-410X DOI: 10.1016/j.vaccine.2006.03.008

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Abstract

We assessed the long-term protection afforded by a killed whole-cell oral cholera vaccine produced in Vietnam. A mass immunization of children and adults with the killed whole-cell oral cholera vaccine was undertaken in half of the communes of Hue, Vietnam, in 1998; the remaining communes were immunized in 2000. No cholera was observed in Hue until 2003, when an outbreak of El Tor cholera made it possible to conduct a case-control study. The overall vaccine effectiveness 3-5 years after vaccination was 50% (9-63%). This low-cost, easily administered vaccine should be considered as a tool for the control of cholera.

Item Type: Article
Keywords: Administration, Oral, Adult, Case-Control Studies, Child, Cholera/epidemiology/*prevention & control, Cholera Vaccines/administration & dosage/*immunology, Confounding Factors (Epidemiology), Disease Outbreaks, Humans, Vietnam/epidemiology, Administration, Oral, Adult, Case-Control Studies, Child, Cholera, epidemiology, prevention & control, Cholera Vaccines, administration & dosage, immunology, Confounding Factors (Epidemiology), Disease Outbreaks, Humans, Vietnam, epidemiology
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Disease Control
Research Centre: Vaccine Centre
PubMed ID: 16580760
Web of Science ID: 238016600008
URI: http://researchonline.lshtm.ac.uk/id/eprint/10277

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