Incidence of diarrhea caused by rotavirus infections in rural Zhengding, China: prospective, population-based surveillance


Wang, XY; Xu, ZY; von Seidlein, L; Zhang, YL; Zhao, SJ; Hao, ZY; Han, OP; Kilgore, P; Xing, ZC; Han, CQ; Ma, JC; Chen, JC; Clemens, J; (2005) Incidence of diarrhea caused by rotavirus infections in rural Zhengding, China: prospective, population-based surveillance. The Journal of infectious diseases, 192 Suppl 1. S100-5. ISSN 0022-1899 DOI: 10.1086/431507

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Abstract

Rotavirus is the pathogen most commonly associated with severe gastroenteritis in young children in the People's Republic of China, yet there are few population-based data on the incidence of rotavirus infection. The present study investigated the burden of rotavirus diarrhea and rotavirus infections in rural China, according to age. Population-based surveillance was used to study the incidence of rotavirus infection among children <5 years of age in 4 townships of Zhengding County, Hebei Province, China. The total population in the catchment area in 2002 was 75,630 individuals, including 2997 children aged <5 years. Stool samples were obtained and were tested for rotavirus antigen by use of an enzyme-linked immunosorbent assay. During 2002, a total of 2010 cases of diarrhea were detected among children <5 years of age. The incidence of treated cases of diarrhea was 671 cases/1000 children/year for children <5 years of age, and it was highest for children <12 months of age (1467 cases/1000 children/year). The estimated incidence of rotavirus infection was 151 cases/1000 children/year for children <5 years of age. The highest incidence of rotavirus infection was among children aged 1-2 years (340 cases/1000 children/year). Widespread immunization of children against rotavirus before 6 months of age should be considered for the control of rotavirus diarrhea.

Item Type: Article
Keywords: Child, Preschool, China/epidemiology, Diarrhea/epidemiology, Humans, Incidence, Infant, Infant, Newborn, Prospective Studies, Rotavirus Infections/*epidemiology, Rural Population, Sentinel Surveillance, Child, Preschool, China, epidemiology, Diarrhea, epidemiology, Humans, Incidence, Infant, Infant, Newborn, Prospective Studies, Rotavirus Infections, epidemiology, Rural Population, Sentinel Surveillance
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Disease Control
Research Centre: Vaccine Centre
PubMed ID: 16088791
Web of Science ID: 231113500015
URI: http://researchonline.lshtm.ac.uk/id/eprint/10262

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