Vaccines against cholera, typhoid fever and shigellosis for developing countries


Acosta, CJ; Galindo, CM; Deen, JL; Ochiai, RL; Lee, HJ; von Seidlein, L; Carbis, R; Clemens, JD; (2004) Vaccines against cholera, typhoid fever and shigellosis for developing countries. Expert opinion on biological therapy, 4 (12). pp. 1939-51. ISSN 1471-2598 DOI: 10.1517/14712598.4.12.1939

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Abstract

Enteric diseases, such as cholera, typhoid fever and shigellosis, still produce a significant burden, especially among the poor in countries where these illnesses are endemic. Older-generation, parenteral, whole-cell vaccines against cholera and typhoid fever were abandoned in many countries as public health tools because of problems with insufficient protection and/or inadequate safety profiles. Modern-generation licensed vaccines are available for cholera and typhoid fever, but are not widely used by those in greatest need. A number of experimental candidates exist for all three diseases. Future research should focus on generating the evidence necessary to obtain a consensus on the deployment of existing vaccines against cholera and typhoid fever, and on clinical evaluation of pipeline vaccine candidates against all three diseases.

Item Type: Article
Keywords: Bacterial Vaccines/*administration & dosage/therapeutic use, Cholera/epidemiology/prevention & control, Cholera Vaccines/*administration & dosage/therapeutic use, Developing Countries/*statistics & numerical data, Dysentery, Bacillary/epidemiology/prevention & control, Humans, Immunization Programs/methods, Shigella Vaccines/*administration & dosage/therapeutic use, Typhoid Fever/epidemiology/prevention & control, Bacterial Vaccines, administration & dosage, therapeutic use, Cholera, epidemiology, prevention & control, Cholera Vaccines, administration & dosage, therapeutic use, Developing Countries, statistics & numerical data, Dysentery, Bacillary, epidemiology, prevention & control, Humans, Immunization Programs, methods, Shigella Vaccines, administration & dosage, therapeutic use, Typhoid Fever, epidemiology, prevention & control
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Disease Control
Research Centre: Vaccine Centre
PubMed ID: 15571456
Web of Science ID: 225680300009
URI: http://researchonline.lshtm.ac.uk/id/eprint/10255

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