Treatment uptake by individuals infected with Plasmodium falciparum in rural Gambia, West Africa


von Seidlein, L; Clarke, S; Alexander, N; Manneh, F; Doherty, T; Pinder, M; Walraven, G; Greenwood, B; (2002) Treatment uptake by individuals infected with Plasmodium falciparum in rural Gambia, West Africa. Bulletin of the World Health Organization, 80 (10). pp. 790-6. ISSN 0042-9686

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Abstract

OBJECTIVE: To find out what proportion of Plasmodium falciparum infections are treated in rural Gambia. METHODS: Subjects from four villages in the Gambia were followed over nine months through visits to village health workers. Monthly cross-sectional malaria surveys measured the prevalence of P. falciparum infection. Linked databases were searched for treatment requests. Treated cases were individuals with parasitaemia who requested treatment during narrow or extended periods (14 or 28 days, respectively) before or after a positive blood film was obtained. FINDINGS: Parasite prevalence peaked in November 1998, when 399/653 (61%) individuals had parasitaemia. Parasite prevalence was highest throughout the study in children aged 5-10 years. Although access to treatment was better than in most of sub-Saharan Africa, only 20% of infected individuals sought medical treatment up to 14 days before or after a positive blood film. Within two months of a positive blood film, 199/726 (27%) individuals with parasitaemia requested treatment. Despite easy access to health care, less than half (42%) of those with parasite densities consistent with malaria attacks (5000/ l) requested treatment. High parasite density and infection during October-November were associated with more frequent treatment requests. Self-treatment was infrequent in study villages: in 3/120 (2.5%) households antimalarial drugs had been used in the preceding malaria season. CONCLUSION: Many P. falciparum infections may be untreated because of their subclinical nature. Intermittent presumptive treatment may reduce morbidity and mortality. It is likely that not all untreated infections were asymptomatic. Qualitative research should explore barriers to treatment uptake, to allow educational interventions to be planned.

Item Type: Article
Keywords: Adolescent, Adult, Aged, Aged, 80 and over, Animals, Antimalarials/*therapeutic use, Child, Child, Preschool, Complementary Therapies, Cross-Sectional Studies, Female, Gambia/epidemiology, Humans, Infant, Malaria, Falciparum/diagnosis/*drug therapy/epidemiology, Male, Middle Aged, Patient Acceptance of Health Care/*statistics & numerical data, Plasmodium falciparum/*isolation & purification, *Rural Health
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Disease Control
Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Faculty of Public Health and Policy > Dept of Social and Environmental Health Research
Research Centre: Malaria Centre
Tropical Epidemiology Group
PubMed ID: 12471399
Web of Science ID: 178776800006
URI: http://researchonline.lshtm.ac.uk/id/eprint/10243

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