Strain-dependent Variation in BCG-induced Human T cell Activation and IFN-{gamma} Production in vitro.


Aguirre-Blanco, AM; Lukey, PT; Cliff, JM; Dockrell, HM; (2007) Strain-dependent Variation in BCG-induced Human T cell Activation and IFN-{gamma} Production in vitro. Infection and immunity, 75 (6). pp. 3197-201. ISSN 0019-9567 DOI: 10.1128/IAI.01611-06

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Abstract

Three commonly used Mycobacterium bovis BCG vaccine strains elicited different magnitudes of T-cell activation and gamma interferon production in vitro in healthy BCG-vaccinated individuals. Glaxo 1077 exhibited the greatest stimulatory capacity, followed by Pasteur 1173 and then Danish 1331. These differences may affect in vitro stimulation and vaccination-induced immunogenicity.

Item Type: Article
Faculty and Department: Academic Services & Administration > Academic Administration
Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Research Centre: TB Centre
Vaccine Centre
PubMed ID: 17387167
Web of Science ID: 246824500065
URI: http://researchonline.lshtm.ac.uk/id/eprint/10216

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