Comparative analysis of two genomic regions among four strains of Buchnera aphidicola, primary endosymbiont of aphids.


Perez-Brocal, V; Latorre, A; Gil, R; Moya, A; (2005) Comparative analysis of two genomic regions among four strains of Buchnera aphidicola, primary endosymbiont of aphids. Gene, 345 (1). pp. 73-80. ISSN 0378-1119 DOI: https://doi.org/10.1016/j.gene.2004.11.021

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Abstract

Preliminary analysis of two selected genomic regions of Buchnera aphidicola BCc, the primary endosymbiont of the cedar aphid Cinara cedri, has revealed a number of interesting features when compared with the corresponding homologous regions of the three B. aphidicola genomes previously sequenced, that are associated with different aphid species. Both regions exhibit a significant reduction in length and gene number in B. aphidicola BCc, as it could be expected since it possess the smallest bacterial genome. However, the observed genome reduction is not even in both regions, as it appears to be dependent on the nature of their gene content. The region fpr-trxA, that contains mainly metabolic genes, has lost almost half of its genes (45.6%) and has reduced 52.9% its length. The reductive process in the region rrl-aroK, that contains mainly ribosomal protein genes, is less dramatic, since it has lost 9.3% of genes and has reduced 15.5% of its length. Length reduction is mainly due to the loss of protein-coding genes, not to the shortening of ORFs or intergenic regions. In both regions, G+C content is about 4% lower in BCc than in the other B. aphidicola strains. However, when only conserved genes and intergenic regions of the four B. aphidicola strains are compared, the G+C reduction is higher in the fpr-trxA region.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
PubMed ID: 15716086
Web of Science ID: 227202000010
URI: http://researchonline.lshtm.ac.uk/id/eprint/10186

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