Effects of piperaquine, chloroquine and amodiaquine on drug uptake and in combination with dihydroartemisinin against drug sensitive and resistant Plasmodium falciparum strains.


Fivelman, QL; Adagu, IS; Warhurst, DC; (2007) Effects of piperaquine, chloroquine and amodiaquine on drug uptake and in combination with dihydroartemisinin against drug sensitive and resistant Plasmodium falciparum strains. Antimicrobial agents and chemotherapy, 51 (6). pp. 2265-7. ISSN 0066-4804 DOI: 10.1128/AAC.01479-06

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Abstract

Piperaquine is being developed as a long-acting component in artemisinin combination therapies. It was highly active in vitro and drug interaction studies showed that dihydroartemisinin combinations with piperaquine, chloroquine, and amodiaquine were indifferent tending toward antagonism. Competitive uptake of radiolabeled chloroquine and dihydroartemisinin in combination with other antimalarials was observed.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
Research Centre: Antimicrobial Resistance Centre (AMR)
Malaria Centre
PubMed ID: 17404003
URI: http://researchonline.lshtm.ac.uk/id/eprint/10179

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