Survival and cure of acute myeloid leukaemia in England, 1971-2006: a population-based study


Shah, A; Andersson, TML; Rachet, B; Bjorkholm, M; Lambert, PC; (2013) Survival and cure of acute myeloid leukaemia in England, 1971-2006: a population-based study. British journal of haematology. ISSN 0007-1048 DOI: 10.1111/bjh.12425

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Abstract

The 5-year relative survival of adults diagnosed with acute myeloid leukaemia (AML) was less than 10% during the 1970s and 1980s in England. This population-based study estimated the 5-year relative survival and ‘cure’ for 48 380 adult patients diagnosed with AML in England during 1971–2006. Relative survival and cure mixture models were used to produce estimates of 5-year relative survival and the percentage ‘cured’. ‘Cure’ was defined as the proportion of a group of survivors for whom there is no excess mortality compared with the general population. The 5-year relative survival and the percentage ‘cured’ increased for patients aged under 70 years at diagnosis during 1971–2006, but advancing age was associated with poorer outcome. During the study period a dramatic increase in 5-year relative survival occurred in those aged 15–24 years, from 7% to 53%. The percentage ‘cured’ was less than 10% for all ages in 1975, but increased to 45% for those aged 15–24 years in 2000. Cure could not be estimated for patients over 70 years, because survival was consistently low (<5%). The long-term outcome of patients with AML has improved substantially, particularly in younger patients. The potential exists for further increasing levels of ‘cure’.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Research Centre: Cancer Survival Group
Centre for Global Non-Communicable Diseases (NCDs)
PubMed ID: 23786647
Web of Science ID: 322025200012
URI: http://researchonline.lshtm.ac.uk/id/eprint/1012208

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