Francisella tularensis vaccines


Griffin, KF; Oyston, PCF; Titball, RW; (2007) Francisella tularensis vaccines. FEMS immunology and medical microbiology, 49 (3). pp. 315-323. ISSN 0928-8244 DOI: 10.1111/j.1574-695X.2007.00219.x

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Abstract

Francisella tularensis is the causative agent of tularaemia, a disease which occurs naturally in some countries in the northern hemisphere. Recently, there has been a high level of interest in devising vaccines against the bacterium because of the potential for it to be used as a bioterrorism agent. Previous human volunteer studies have shown that a strain of F. tularensis [the live vaccine strain (LVS)] that has been attenuated by laboratory passage is effective in humans as a vaccine against airborne disease. However, for a variety of reasons it seems unlikely that the LVS strain will be licensed for use in humans. Against this background there is an effort to devise a licensable vaccine against tularaemia. The prospects for a killed whole-cell subunit of live attenuated vaccine are reviewed. A rationally attenuated mutant seems the most likely route to a new tularaemia vaccine.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
Research Centre: Vaccine Centre
PubMed ID: 17316369
Web of Science ID: 244980400001
URI: http://researchonline.lshtm.ac.uk/id/eprint/10043

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